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Thorne Research Calcium D-Glucarate $39.40/Bottle of 90 Thorne Research M280

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- Calcium D-Glucarate (M280)

By Thorne Research

$39.40 / Bottle of 90

MSRP $49.00 You Save $9.60

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What you get:

  • Condition: New
  • Brand: Thorne Research
  • Product ID / Part Number: M280
  • Packages/Order: 1
  • Package Type: Capsule
  • Total Units: 90
  • Order Size: Bottle
  • Unit Price: $0.437
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Calcium D-Glucarate (CDG) has been shown to promote liver detoxification by enhancing the metabolism of hormones and environmental toxins.* It also helps maintain normal cholesterol levels.*

Serving Size: 1 Capsules
Servings Per Container: 90

Supports:
Liver Detox, Metabolism of Hormones and Xenobiotics

How to Use:
Take 1 capsule three times daily or as recommended by your health professional.

Ingredient Amounts:
Calcium................................62mg
Calcium D-Glucarate............500mg
Other Ingredients: Hypromellose Capsule, Leucine



Calcium D-Glucarate Details:
Calcium D-Glucarate (CDG) is produced naturally in small amounts by humans. CDG supplementation has been shown to prevent the recycling of hormones and undesirable environmental toxins, thereby promoting liver detoxification and the excretion of these potentially detrimental substances.* Other applications of CDG supplementation include the maintenance of already normal cholesterol levels and facilitating healthy hormone metabolism.*

How does it work?
Glucuronidation is the liver's normal process of attaching a glucuronic acid molecule to potentially harmful substances to detoxify and eliminate them from the body.* During phase II liver detoxification, certain hormones and various fat-soluble toxins will undergo glucuronidation and be excreted through the bile or urine. Calcium D-Glucarate helps this elimination process to occur uninterrupted.*

The more detailed version: Upon ingestion and exposure to the acidic environment of the stomach, Calcium D-Glucarate is metabolized to form D-glucaric acid. D-glucaric acid is further metabolized in the gastrointestinal tract into three compounds that exist in equilibrium and are comprised of approximately 40-percent D-glucaric acid, 30-percent D-glucaro-1,4-lactone, and 30-percent D-glucaro-6,3-lactone. These compounds are then transported to the blood and various internal organs, and subsequently excreted in the urine and bile. Although D-glucaro-1,4-lactone is apparently the most pharmacologically active of the three, it is not commercially available. Also, Calcium D-Glucarate administration results in longer inhibition of beta-glucuronidase (five hours versus one hour) than does D-glucaro-1,4-lactone, so it is the compound used.*

Calcium D-Glucarate's detoxifying and chemopreventive properties are attributable to its ability to increase glucuronidation, and the accompanying excretion of harmful compounds.* It does so by inhibiting the enzyme beta-glucuronidase.* During Phase II detoxification, hormones and various undesirable lipid-soluble toxins are bound to glucuronic acid in the liver (glucuronidation) and excreted through the biliary tract; however, beta-glucuronidase can unbind these toxins, which makes it possible for them to be reabsorbed rather than excreted. D-glucaro-1,4-lactone is the metabolite that most inhibits the activity of beta-glucuronidase, thereby increasing the excretion of toxic compounds and decreasing the activity of harmful substances that are most active in their unbound state.* Inhibition of beta-glucuronidase by Calcium D-Glucarate metabolites ultimately results in potentially decreasing the risk of toxicity.*

In addition, by reducing the activity of beta-glucuronidase and the viability of harmful intestinal bacteria, the salts of D-glucaric acid have been shown to enhance enterohepatic circulation and reduce cholesterol synthesis, thus resulting in maintenance of healthy cholesterol levels.*

SKU: M280
HCPCS: 693749280026

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*Full Refund within 30 days of purchase. *75% Refund after 30 days of purchase. *75% Credit exceeding 3 months. 10% administration fee. Shipping is paid for by the customer. Original packaging. No returns after 30 days. No Cancellations; No Returns on PPE or PPE-related products; All Sales Final. Not all products are eligible for returns. Exclusions may apply. Please refer to the "Restrictions" tab on the products listing page, i.e. where stated "Non-Returnable Item". All returns must be approved by our Returns Department. An e-mail notification will be issued regarding your return status and return instructions, should this apply. Any product returned for credit without an authorized RMA number clearly printed on the outside package or shipping label will be refused. Unauthorized returns will not be honored or accepted for credit.

Allergy Warnings:
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

Pregnancy Warnings:
If pregnant, consult your health professional before using this product.

Interactions:
There are no known adverse interactions or contraindications at publication date.

Thorne Research

Thorne Research:
For over 30 years, Thorne Research has been dedicated to enhancing the health and well-being of people worldwide by providing innovative, high-quality, research-based nutritional supplements, health diagnostics technology platforms, and the latest in medical education.

Through our products and services, our passionate, talented staff, collaboration with a variety of innovative and expert strategic partners, and an unwavering commitment to integrity, Thorne Research strives to become a leading health-care company serving people around the world.

Products include the likes of Cardiovascular Support, Detox/Liver Support, Nutrition Gastrointestinal Support, Immune Support, Metabolic/Weight Management, Musculoskeletal Support, Neurological Support, Oncology Supportive, Sports Performance and more.

For consumer use only. Not for resale.

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